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Has anyone tried Azodyl and know a few things about it?

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  • Has anyone tried Azodyl and know a few things about it?

    Yesterday the vet said that my Sam has a possible kidney infection. I think he probably feels like it's more than that though. He didn't go into detail but said that there is a high amount of protein in the urine where two months ago there was only a trace. The second thing, he mentioned in passing, was that he would like Sam to drink broth. He also added that he didn't want the sodium free or low sodium kind. He wanted him to drink the kind with sodium in it.

    I'm a nurse (for humans) and am a bit wary. His manner (the vet's) was nervous and body language can often tell so much more than words can. I'm trained to recognize body language in people and I am familiar with my vet. This makes me believe that he's not wanting to give me bad news (yet).

    All that said, Sam is on an antibiotic (he had an ear infection too) and Azodyl. I'm not familiar with canine drugs at all. I'm thinking Azodyl may be the pet equivalent to the human nephrovite. Am I right?

    Unfortunately when I Googled Azodyl, I'm not getting much in the way of information on it. I see it is used for kidney disease and is a "nutritional supplement," I can find tons of stats about side effects but I cannot find anywhere what is actually in it and how it works. A "nutritional supplement" is very vague and can mean a variety of things. For example, taking green tea extract is taking a nutritional supplement, but green tea is not a vitamin per say. It may enchance vitamin metabolism, but it is not a real vitamin.

    So, my question is what exactly IS Azodyl? I've read about side effects and such, and I'm not interested in that part. I fully understand renal disease/failure and the like. I just want to know what is in it and how it (the Azodyl) works.

    If anyone knows or has links that I can't find, I'd be very grateful.


  • #2
    There have been a number of threads about it in this forum. Here is a link to a recent one:

    Vomiting is a major problem. This one was in the cat forum, but if you search under Azodyl under the tab on the upper portion of this forum, you will see the search button.


    • #3
      Hello and welcome to the forum! Did your vet do blood work on Sammy to diagnose kidney failure?

      I know only a little about azodyl, and there is another member who had a kitty on it last year.

      The most troublesome side affect is nausea. And a pet who feels sick isn't going to eat so it can be a big problem.

      From what I understood, back at the time my vet and I were discussing this to use for my
      Ootay (rb 5/09), azodyl works to draw the urea nitrogen out of the blood.

      Kidney disease patients often present with a high BUN number, Blood Urea Nitrogen. Azodyl some how bonds to the uric acid, removing it from the blood so it does not pass through the kidneys. I think it may go through the liver instead, but I'm not positive about that part.

      Because of the nausea side affect I did not try it for Ootay, because she had many other issues that already affected her tummy and appetite.

      I'll see if I can find the link I had on it a while back.

      By the way, if you feel your vet won't level with you, you might want to get a second opinion. Tell him you need him to be honest with you, because working as a team with your vet is crucial to keeping Sammy in the best health he can be with this, or any other, chronic illness.



      • #4
        i had my Sam(rb) on Azodyl for a little while, about two years ago; he was 19 and diabetic; his kidney function was slowly getting less and the doctor wanted to try it. as far as we could tell it didn't have that much effect. i made some dietary changes and his kidney function stabilized. since Sam was a cat, your mileage may vary.

        i believe Azodyl is a probiotic of a sort, and as such, might be inhibited by antibiotics given concurrently. you may want to check with your vet.



        • #5
          Thanks for the responses so far. Evidently I've not properly worded my question. What I'm wanting to know is HOW this drug works and WHAT the ingredients are. For example, you can look up Nyquil and see that it actually contains tylenol, dextromethorphan and so forth. Hopefully that clarifies things a bit better.

          I still am not really interested in side effects, as I've read (extensively) about those. Also, I'm actually speaking about a dog. A search in the dog forum yields no result, unfortunately.

          My vet did do a lot of tests. I'm not really asking about that though either. I'm familiar with all of that. Also my vet is the one that prescribed it along with the antibiotics.


          • #6
            This link may provide you with some background for dogs and kidney disease:


            From the link: Azodyl is a proprietary probiotic product that claims to help break down the by-products of digestion that contribute to uremia (elevated creatinine and BUN). Note that uremia contributes to symptoms of kidney disease, but is not harmful to the kidneys themselves; elevated creatinine and BUN are the result of kidney disease, not the cause. The bacteria are called "Kibow probiotics", from Kibow Biotech in Pennsylvania, who sells the same product under their own brand name, and says it contains three strands of probiotics: streptococcus thermophilus, lactobacillus acidophilus, and bifidobacterium longum, plus psyllium (prebiotic, used to feed the probiotics). See this info in their brochure. This company apparently patented the term "enteric dialysis" that is used to market Azodyl. Once again, you may be able to find these ingredients more cheaply in other probiotics products, such as Source Naturals Life Flora, Udo's Choice (available thru Amazon), and Stonyfield Farm Yogurt. See this ConsumerLab report for other good probiotic brands. Also see PDRHealth for more general info on these and other probiotic strains.

            For ingredients: AZODYL™ NUTRITIONAL SUPPLEMENT Veterinary Use Only COMPOSITION Ingredients: Kibow Biotics® [E. thermophilus (KB 19), L. acidophilus (KB 27), B. longum (KB 31), Psyllium husk].

            From a Natural Foods site: Azodyl…Suports Kidney Function by providing NATURAL inter-renal Dialysis and slows down toxic buildup in the blood and helps prevent further kidney damage. This naturally-occurring beneficial bacteria reduces azotemia in dogs and cats by metabolizing and flushing out toxins through the bowel.


            • #7
              Good info there, Calico!! I'm concerned about the prescription of antibiotics AND a probiotic - the probiotic would probably do a nice job of preventing nausea, but what's the antibiotic treating? The ear infection? But then, why go for broth with a high sodium content? I would think it would be counter-productive to increase the amount of work the kidneys are doing.

              I don't have anything to add except that it's worthwhile to get a second opinion in a situation where you feel that a vet is not being entirely upfront about what's going on. The vet may be hesitant about giving you bad news, or perhaps is worried but doesn't know WHAT is wrong and thus they don't know where to start.

              I'd check around - if there's a vet college in your area, it would be worth taking the dog in for some tests there. Bring your results from your regular vet (it's not uncommon, if a vet school is in the area, to do a consultation with an internal medicine specialist, so it's highly unlikely your vet will have a problem with this), as that will give a history over time, even if it is a matter of days or weeks. Additionally, you could see if an ultrasound would be a good idea - if there's kidney function issues, and it's a sudden change, I'd be very concerned.

              (not a vet, but a second opinion, and even a third, has saved us some major grief)
              ----with Sadie, Elsie, Saffron, Peaches & James ----


              • #8
                Hi and welcome to the forum!! I'm wondering if your vet is concerned about your dog losing salt through excessive urination as would be seen in diabetes insipitus, as one of the things Azodyl does is balance salt. I'm thinking that you should have a more detailed discussion with the vet. As a health professional you have a better understanding about these issues than most lay people and the vet should be willing to be up front with you about your dog's condition and why he wants the dog to be eating broth with salt and taking this medication. Ask him to put it into sentences with verbs <GGG>
                Diane and Cicero - Sr. Manager:


                • #9
                  Azodyl acts as dialysis, yeah, that's the word I was trying to think of.

                  But I recommend you write your questions down so you don't forget any, and bring them to your vet. Write down the answers too, so you have a reference. And if your vet won't or can't answer them to your satisfaction go else where. Vagueness is not acceptable.

                  Did Sam have blood work? What were his numbers like?

                  Please let us know how he's doing.




                  • #10
                    As long as your dog can hold it down it is not likely to cause any problems. As a nutritional supplement, as you know, there is no requirement for safety and efficacy trials before it can be sold.

                    I'm a bit perplexed about the high sodium broth. Renal disease is often accompanied by hypertension, so controlling the sodium and the phosphorus is important. OTOH, he may be using that to encourage production of large volumes of urine for the purpose of dilution. It would be informative to have the urinalysis results, blood panel results, and a blood pressure.
                    Dr. Gus


                    • #11
                      Azodyl replacement

                      Looking for a replacement for Azodyl for my dog with CRF. HELP! I've been reading the threads re Azodyl, but most of the postings are about cats, and I don't really find solid information I can grab onto and run with. I keep leaving the Azodyl bottle on the kitchen counter and probably killed the bacterias weeks ago. Stella is loving Trader Joe's Organic Vanilla Yogurt with Probiotics, and I was thinking of adding another probiotics supplement from the health food store -- thus eliminating the need for the Azodyl. Yes? No? Maybe?

                      Her numbers have improved dramatically, probably mostly due to the subcutaneous hydration I'm doing at home every other day. Am using canned and kibbled Hill's and Purina food for kidney disease until I can figure out how to make my own food.

                      Thank you,


                      • #12
                        If you are using a prescription food for kidney disease, I wouldn't change it. After all, the companies formulated the food for specific reasons, not simply for the sake of change. And major food companies have the resources to develop special diets for special problems.

                        While there may be recipes on the web, how do you know just exactly why they are good, other then a person's claim. Or anecdotal information.

                        And yes, hydration may be the biggest factor in the positive changes.


                        • #13
                          I also have a dog with CRF, Tilly, who's 15, and frankly, I have no information on Azodyl, I wish I could say I did. All I can find on the net is that it's some sort of probiotic. Not sure how that's supposed to work, as even according to it's manufacturer's site, it's lower GI tract bacteria....why that would help is beyond me.

                          You could certainly try an acidophilous bacteria combo, or another probiotic, but if it doesn't hurt and isn't too expensive, well, why switch? But if it's too expensive, or too fragile, then I could see trying something different. But the probiotic we use (in an attempt to keep her tummy happy since the CRF means her appetite goes to the dumps every so often and that means major food changes to keep her eating) is just a regular refrigerated chewable acidophilous tablet.

                          Are you using any kind of phosphorus binder (besides the Azodyl - sounds like that's SORT OF what it might be doing)? What's working for us is a combo of Epakitin and aluminum hydroxide (mylanta, basically). Tilly is probably further along in the stages of CRF, as we're having to do more to keep those numbers under control. How much fluids are you doing? We're at 300 ml every day to 350 ml, and that's working well (she's only a 30 lb dog).

                          Keep feeding the prescription Hill's if you can get it down the dog - Tilly LOVED the stuff until we hit a crisis with her kidney values, and then suddenly it was a battle to get any food into her. Save the homemade diets for when you really need it to keep the dog eating ANYTHING. That novelty of "ooooh, chicken!" is what kept Tilly eating at a time when I was worried I was going to lose her. She was surviving on chicken breast, broth and air. We got to the point where we figured out exactly how much chicken we could give her every day to get some food into her without overloading her on the protein values (exactly 2.3 ounces, or a third of a good sized chicken breast - I can now slice nearly exactly right, only have to pick a little bit off each one to get the numbers we want). So keep the homemade diets for when you really need them. A good friend of mine lost her dog to this as well, a dog Tilly was puppies with, right about the time I was having so much trouble with Tilly this spring, and I still think it was the loss in body weight - Tilly only lost about a tenth of her weight, whereas her best friend lost a third of her body weight. That dog went downhill much faster.

                          Hang in there, and I'd love to hear more about your dog and how you've been doing with the CRF.

                          Hope this helps,
                          ----with Sadie, Elsie, Saffron, Peaches & James ----


                          • #14
                            I tried looking up the ingredients for Azodyl. Other than the bacteria that is stated on a website that isnt the Azodyl website. There is absolutly no info on the ingredients. I looked up bergies manual on bacteria and the strains (KB19) do not show up as valid strains. So, this is what ive come to discover. The company website doesnt not tell you what is in the product. The ingredients other than the bacteria cannot be found. They also do not tell you how many CFU/g are in each dose. The bacterial strains also do not seem to be valid. They look to be made up by somoe marketing guy. There are hundreds of strains of L. acidophilus. But theirs doesnt seem to be a valid name. So what is it? I don't want to say this product is a scam but if the main company that produces is doesnt give you the FULL ingredients something is wrong with it. What are they hiding?
                            Last edited by LokiJack; 12-29-2010, 07:36 PM. Reason: typos