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Thread: Has anyone tried Azodyl and know a few things about it?

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    New Member magnoliasouth's Avatar
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    Default Has anyone tried Azodyl and know a few things about it?

    Yesterday the vet said that my Sam has a possible kidney infection. I think he probably feels like it's more than that though. He didn't go into detail but said that there is a high amount of protein in the urine where two months ago there was only a trace. The second thing, he mentioned in passing, was that he would like Sam to drink broth. He also added that he didn't want the sodium free or low sodium kind. He wanted him to drink the kind with sodium in it.

    I'm a nurse (for humans) and am a bit wary. His manner (the vet's) was nervous and body language can often tell so much more than words can. I'm trained to recognize body language in people and I am familiar with my vet. This makes me believe that he's not wanting to give me bad news (yet).

    All that said, Sam is on an antibiotic (he had an ear infection too) and Azodyl. I'm not familiar with canine drugs at all. I'm thinking Azodyl may be the pet equivalent to the human nephrovite. Am I right?

    Unfortunately when I Googled Azodyl, I'm not getting much in the way of information on it. I see it is used for kidney disease and is a "nutritional supplement," I can find tons of stats about side effects but I cannot find anywhere what is actually in it and how it works. A "nutritional supplement" is very vague and can mean a variety of things. For example, taking green tea extract is taking a nutritional supplement, but green tea is not a vitamin per say. It may enchance vitamin metabolism, but it is not a real vitamin.

    So, my question is what exactly IS Azodyl? I've read about side effects and such, and I'm not interested in that part. I fully understand renal disease/failure and the like. I just want to know what is in it and how it (the Azodyl) works.

    If anyone knows or has links that I can't find, I'd be very grateful.

    TIA!

  2. #2
    Senior Member calicokitty's Avatar
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    There have been a number of threads about it in this forum. Here is a link to a recent one: http://www.thepetsforums.com/forums/...ghlight=azodyl

    Vomiting is a major problem. This one was in the cat forum, but if you search under Azodyl under the tab on the upper portion of this forum, you will see the search button.

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    Senior Member GailS's Avatar
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    Hello and welcome to the forum! Did your vet do blood work on Sammy to diagnose kidney failure?

    I know only a little about azodyl, and there is another member who had a kitty on it last year.

    The most troublesome side affect is nausea. And a pet who feels sick isn't going to eat so it can be a big problem.

    From what I understood, back at the time my vet and I were discussing this to use for my
    Ootay (rb 5/09), azodyl works to draw the urea nitrogen out of the blood.

    Kidney disease patients often present with a high BUN number, Blood Urea Nitrogen. Azodyl some how bonds to the uric acid, removing it from the blood so it does not pass through the kidneys. I think it may go through the liver instead, but I'm not positive about that part.

    Because of the nausea side affect I did not try it for Ootay, because she had many other issues that already affected her tummy and appetite.

    I'll see if I can find the link I had on it a while back.

    By the way, if you feel your vet won't level with you, you might want to get a second opinion. Tell him you need him to be honest with you, because working as a team with your vet is crucial to keeping Sammy in the best health he can be with this, or any other, chronic illness.

    Gail

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    i had my Sam(rb) on Azodyl for a little while, about two years ago; he was 19 and diabetic; his kidney function was slowly getting less and the doctor wanted to try it. as far as we could tell it didn't have that much effect. i made some dietary changes and his kidney function stabilized. since Sam was a cat, your mileage may vary.

    i believe Azodyl is a probiotic of a sort, and as such, might be inhibited by antibiotics given concurrently. you may want to check with your vet.

    .m

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    New Member magnoliasouth's Avatar
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    Thanks for the responses so far. Evidently I've not properly worded my question. What I'm wanting to know is HOW this drug works and WHAT the ingredients are. For example, you can look up Nyquil and see that it actually contains tylenol, dextromethorphan and so forth. Hopefully that clarifies things a bit better.

    I still am not really interested in side effects, as I've read (extensively) about those. Also, I'm actually speaking about a dog. A search in the dog forum yields no result, unfortunately.

    My vet did do a lot of tests. I'm not really asking about that though either. I'm familiar with all of that. Also my vet is the one that prescribed it along with the antibiotics.

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    Senior Member calicokitty's Avatar
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    This link may provide you with some background for dogs and kidney disease:

    http://www.dogaware.com/kidney.html

    From the link: Azodyl is a proprietary probiotic product that claims to help break down the by-products of digestion that contribute to uremia (elevated creatinine and BUN). Note that uremia contributes to symptoms of kidney disease, but is not harmful to the kidneys themselves; elevated creatinine and BUN are the result of kidney disease, not the cause. The bacteria are called "Kibow probiotics", from Kibow Biotech in Pennsylvania, who sells the same product under their own brand name, and says it contains three strands of probiotics: streptococcus thermophilus, lactobacillus acidophilus, and bifidobacterium longum, plus psyllium (prebiotic, used to feed the probiotics). See this info in their brochure. This company apparently patented the term "enteric dialysis" that is used to market Azodyl. Once again, you may be able to find these ingredients more cheaply in other probiotics products, such as Source Naturals Life Flora, Udo's Choice (available thru Amazon), and Stonyfield Farm Yogurt. See this ConsumerLab report for other good probiotic brands. Also see PDRHealth for more general info on these and other probiotic strains.

    For ingredients: AZODYL™ NUTRITIONAL SUPPLEMENT Veterinary Use Only COMPOSITION Ingredients: Kibow Biotics® [E. thermophilus (KB 19), L. acidophilus (KB 27), B. longum (KB 31), Psyllium husk]. http://www.medi-vet.com/prod-Azodyl_...ules-3088.aspx

    From a Natural Foods site: Azodyl…Suports Kidney Function by providing NATURAL inter-renal Dialysis and slows down toxic buildup in the blood and helps prevent further kidney damage. This naturally-occurring beneficial bacteria reduces azotemia in dogs and cats by metabolizing and flushing out toxins through the bowel.
    http://www.drfry.biz/whats_new_2.html

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    Staff MaryH's Avatar
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    Good info there, Calico!! I'm concerned about the prescription of antibiotics AND a probiotic - the probiotic would probably do a nice job of preventing nausea, but what's the antibiotic treating? The ear infection? But then, why go for broth with a high sodium content? I would think it would be counter-productive to increase the amount of work the kidneys are doing.

    I don't have anything to add except that it's worthwhile to get a second opinion in a situation where you feel that a vet is not being entirely upfront about what's going on. The vet may be hesitant about giving you bad news, or perhaps is worried but doesn't know WHAT is wrong and thus they don't know where to start.

    I'd check around - if there's a vet college in your area, it would be worth taking the dog in for some tests there. Bring your results from your regular vet (it's not uncommon, if a vet school is in the area, to do a consultation with an internal medicine specialist, so it's highly unlikely your vet will have a problem with this), as that will give a history over time, even if it is a matter of days or weeks. Additionally, you could see if an ultrasound would be a good idea - if there's kidney function issues, and it's a sudden change, I'd be very concerned.

    -Mary
    (not a vet, but a second opinion, and even a third, has saved us some major grief)
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    Staff DianeP's Avatar
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    Hi and welcome to the forum!! I'm wondering if your vet is concerned about your dog losing salt through excessive urination as would be seen in diabetes insipitus, as one of the things Azodyl does is balance salt. I'm thinking that you should have a more detailed discussion with the vet. As a health professional you have a better understanding about these issues than most lay people and the vet should be willing to be up front with you about your dog's condition and why he wants the dog to be eating broth with salt and taking this medication. Ask him to put it into sentences with verbs <GGG>
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    Senior Member GailS's Avatar
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    Azodyl acts as dialysis, yeah, that's the word I was trying to think of.

    But I recommend you write your questions down so you don't forget any, and bring them to your vet. Write down the answers too, so you have a reference. And if your vet won't or can't answer them to your satisfaction go else where. Vagueness is not acceptable.

    Did Sam have blood work? What were his numbers like?

    Please let us know how he's doing.

    Gail

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    Staff - Veterinary DrGus's Avatar
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    As long as your dog can hold it down it is not likely to cause any problems. As a nutritional supplement, as you know, there is no requirement for safety and efficacy trials before it can be sold.

    I'm a bit perplexed about the high sodium broth. Renal disease is often accompanied by hypertension, so controlling the sodium and the phosphorus is important. OTOH, he may be using that to encourage production of large volumes of urine for the purpose of dilution. It would be informative to have the urinalysis results, blood panel results, and a blood pressure.
    Dr. Gus

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