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Thread: Use of Cerenia for IBS in cats

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    Question Use of Cerenia for IBS in cats

    Cerenia (tm, undoubtedly) is marketed as a remedy for motion sickness in dogs. However, a friend who has a senior male cat has reported that Cerenia helped stop his vomiting. The cat is 17 now and had a diagnosis of IBS many years ago. The Cerenia was injected at need - a few times a year for a year or so - and was last used three years ago (implying the recurring vomiting has subsided, for whatever reason).

    One of my cats has IBS and manages with diet and prednisone (via transdermal gel). His primary symptom is diarrhea but he vomits on the same day he has the runs. Prednisone is strong stuff and I'd like to know if there is a safe alternative, so I am wondering about the Cerenia.

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    Senior Member calicokitty's Avatar
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    Use in nausea in cats:

    http://winnfelinehealth.blogspot.com...a-in-cats.html
    http://www.ema.europa.eu/ema/index.j...01ac058001fa1c

    In lesser peer reviewed comments:

    http://thelearningvet.wordpress.com/...thout-cerenia/

    From scanning various articles, vets use it for prevention of vomiting, and some use in diabetes, but contraindicated for a cat with liver problems.

    So ask your vet about using it to prevent vomiting, and perhaps some mashed pumpkin for the fiber to help with the diarrhea.

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    Staff - Veterinary DrGus's Avatar
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    Current dosage recommendation for Cerenia in cats (all off label):

    Anti-emetic -- 0.5-1.0 mg/kg body weight (either injectable or oral tablets) daily for 5 days, then every other day.

    Anti-inflammatory (rhinitis, urinary tract disease or urethral obstruction, chronic upper respiratory, gastritis, intestinal inflammatory disease, etc.) -- 2 mg/kg of LEAN muscle mass daily for 5 days, skip two days, then give twice weekly.

    As a selective NK1 receptor antagonist it may also be effective in addressing neurogenic inflammation and pain by inhibiting the neuromodulator Sub P.
    Dr. Gus

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    Senior Member Siena's Avatar
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    When Boo's immune system collapsed last year, after doing her innoculations, she was vomitting on the 6th day. Our vet gave her one shot of Cerenia, and it stopped.

    Having said that, Boo had no other health issues - so I don't know if it would be contra-indicated in that case.

    With Latte's almost constant vomitting and diarrhea, as part of her Inflammatory Bowel Disease and Pancreatis, no vet ever suggested using it because her conditions were ongoing and not occasional.

    I'd call my vet if I was wondering.
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    FWIW, the FDA-CVM has now approved Cerenia injectable for use in cats 16 weeks of ager or older for the treatment of vomiting at a dose of 1.0 mlg/kg body weight (0.45 mg.lb bw) once daily for up to five days. In hospice cases it can be used five days on, one day off, five days on, etc.
    Dr. Gus

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    Senior Member Siena's Avatar
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    Quote Originally Posted by DrGus View Post
    FWIW, the FDA-CVM has now approved Cerenia injectable for use in cats 16 weeks of ager or older for the treatment of vomiting at a dose of 1.0 mlg/kg body weight (0.45 mg.lb bw) once daily for up to five days. In hospice cases it can be used five days on, one day off, five days on, etc.
    Dr. Gus...would it have side effects, such as making, say, renal or liver problems worse? Sometimes in a cat with multiple issues, the treatment for one can worsen the other..
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    y I have a healthy cat of about 5 years of age. She has vomited continuously - daily or 3 or 4 times a week for years. It has been investigated. She is healthy and feels great despite the vomiting. Then I tried Cerenia. It appears to be a miracle but my vet says it can only be used for 5 days and is not for long-term use.. Are there any authoritative or published articles indicating its safety for long term use? Thank you.

    Janice

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    Default Cerenia the miracle drug

    Quote Originally Posted by jchadola View Post
    y I have a healthy cat of about 5 years of age. She has vomited continuously - daily or 3 or 4 times a week for years. It has been investigated. She is healthy and feels great despite the vomiting. Then I tried Cerenia. It appears to be a miracle but my vet says it can only be used for 5 days and is not for long-term use.. Are there any authoritative or published articles indicating its safety for long term use? Thank you.

    Janice
    I have my cat, 9 yo domestic short hair, on Cerenia for vomiting. He is inder the care of a specialist and they have done exploratory, ultrasound, endoscopy along with several blood draws with no definitive diagnosis to this day (all started Oct. 22). I have been dosing him with 1/2 tab of the 24 mg daily along with metoclopromide and cisapride twice daily. My vet has not told me it couldn't be used long term and I did see a post of another pet owner whose vet was giving their 17 yo cat 1/4 tab daily. Do you know why your vet said not for use long term? Do you have a response related to published articles, etc.?

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    Hi-as I understand it, Cerenia can cause tremors if used on a long term basis. I have seen on the Internet that it has been used on a long-term basis with a break about every couple of days. There is a website called the learning vet where Cerenia is discussed. Cerenia is $7 a tablet in Canada which is expensive. I could not buy it from the US where it is less expensive unless i had a US vet prescribe it and/or had a US address to have it delivered to. My vet put my kitty on liquid cisapride; however it was taken off the Canadian market for human use because it could cause fatal heart problems although it could still be prescribed for veterinary use. Even if it did not cause the same heart problems in cats, I did not want to risk giving it to my cat. I only found out about the potentially fatal effects in humans accidentally when my doctor happened to mention it so I researched it more on the Internet. As I did not want to use it for my cat, he put her on metaclopramide 1-1/2 of a 5 mg tablet twice a day. Now she vomits infrequently. I was given a prescription so I could have the pharmacy compound a liquid chicken flavoured concentrated form but she threw up shortly after giving it to her once so I have stayed with the tablets. To save my fingers I have had to use a "pill popper" with a rubber part at the end so I can insert it down her throat far enough that she cannot spit it out. I just hope it keeps working.

    Janice

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    Quote Originally Posted by jchadola View Post
    Hi-as I understand it, Cerenia can cause tremors if used on a long term basis. I have seen on the Internet that it has been used on a long-term basis with a break about every couple of days. There is a website called the learning vet where Cerenia is discussed. Cerenia is $7 a tablet in Canada which is expensive. I could not buy it from the US where it is less expensive unless i had a US vet prescribe it and/or had a US address to have it delivered to. My vet put my kitty on liquid cisapride; however it was taken off the Canadian market for human use because it could cause fatal heart problems although it could still be prescribed for veterinary use. Even if it did not cause the same heart problems in cats, I did not want to risk giving it to my cat. I only found out about the potentially fatal effects in humans accidentally when my doctor happened to mention it so I researched it more on the Internet. As I did not want to use it for my cat, he put her on metaclopramide 1-1/2 of a 5 mg tablet twice a day. Now she vomits infrequently. I was given a prescription so I could have the pharmacy compound a liquid chicken flavoured concentrated form but she threw up shortly after giving it to her once so I have stayed with the tablets. To save my fingers I have had to use a "pill popper" with a rubber part at the end so I can insert it down her throat far enough that she cannot spit it out. I just hope it keeps working.

    Janice
    Janice I am giving the cisapride and metoclopromide (Reglan) twice daily. I tried to give just the Reglan by itself but he still vomited. I was giving just a 1/2 tablet of Cerenia and did it for 5 days then took a break to see if just the other 2 would be sufficient. When he was sickest I was feeding him through an E-tube which was inserted in his neck and went into the esophagus but now it;s just with a syringe and I have to fight him everyday. May look into the pill popper and switch to a tablet form of the Reglan. Would still have to give the cisapride by syringe but it is a very small amount (0.25 cc) so it would get in faster. Thanks for the info.
    Pamela

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